(R)-3-Nitrobiphenyline

(R)-3-Nitrobiphenyline
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Systematic (IUPAC) name
	(R)-2-[1-(3'-Nitrobiphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole
Clinical data
MedlinePlus	a682611
Identifiers
CAS Registry Number	7px
PubChem	CID 16757089
ChemSpider	23288036 7px
ChEMBL	CHEMBL242693 7px
Chemical data
Formula	C17H17N3O3
Molecular mass	311.334 g/mol
	SMILES c2ccc([N](=O)=O)cc2-c1ccccc1OC(C)C3=NCCN3;
	InChI InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)/t12-/m1/s1 7px ; Key:NMSAVNXFCXMJJY-GFCCVEGCSA-N 7px ;
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(R)-3-Nitrobiphenyline is a drug which acts as an α₂-adrenergic agonist, selective for the α_2C subtype, as well as being a weak antagonist at the α_2A and α_2B subtypes.^[1]

References

^ Crassous PA, Cardinaletti C, Carrieri A, Bruni B, Di Vaira M, Gentili F, Ghelfi F, Giannella M, Paris H, Piergentili A, Quaglia W, Schaak S, Vesprini C, Pigini M (August 2007). "Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist". Journal of Medicinal Chemistry 50 (16): 3964–8. PMID 17630725. doi:10.1021/jm061487a.

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[pmid17630725-1] Crassous PA, Cardinaletti C, Carrieri A, Bruni B, Di Vaira M, Gentili F, Ghelfi F, Giannella M, Paris H, Piergentili A, Quaglia W, Schaak S, Vesprini C, Pigini M (August 2007). "Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist". Journal of Medicinal Chemistry 50 (16): 3964–8. PMID 17630725. doi:10.1021/jm061487a.

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(R)-3-Nitrobiphenyline

References