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Open Access Articles- Top Results for 3-Hydroxyphenazepam

3-Hydroxyphenazepam

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3-Hydroxyphenazepam
File:3-Hydroxyphenazepam.svg
Systematic (IUPAC) name
7-Bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Clinical data
Identifiers
70030-11-4
None
PubChem CID 125820
ChemSpider 111897
Chemical data
Formula C15H10BrClN2O2
365.609 g/mol

3-Hydroxyphenazepam is a benzodiazepine with hypnotic, sedative, anxiolytic, and anticonvulsant properties.[1] It is an active metabolite of phenazepam,[1][2] as well as the active metabolite of the benzodiazepine prodrug cinazepam.[3] Relative to phenazepam, 3-hydroxyphenazepam has diminished myorelaxant properties, but is about equivalent in most other regards.[1] Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.[4][5]

References

  1. ^ a b c Artur Viktorovich Valʹdman (31 May 1986). Drug dependence and emotional behavior: neurophysiological and neurochemical approaches. Consultants Bureau. ISBN 978-0-306-10984-3. 
  2. ^ Lukasz Komsta; Monika Waksmundzka-Hajnos; Joseph Sherma (20 December 2013). Thin Layer Chromatography in Drug Analysis. CRC Press. pp. 299–. ISBN 978-1-4665-0715-9. 
  3. ^ Schukin SI, Zinkovsky VG, Zhuk OV (2011). "Elimination kinetics of the novel prodrug cinazepam possessing psychotropic activity in mice" (PDF). Pharmacol Rep 63 (5): 1093–100. PMID 22180351. 
  4. ^ Kopanitsa, M. V.; Zbarska, S. M.; Boychuk, Ya. A.; Krishtal, O. A. (2000). "Modulation of GABA-activated currents by phenazepam and its metabolites in isolated rat purkinje neurons". Neurophysiology 32 (3): 192–192. ISSN 0090-2977. doi:10.1007/BF02506568. 
  5. ^ Golovenko, N. Ya; Larionov, V. B. (2014). "Pharmacodynamical and Neuroreceptor Analysis of the Permeability of the Blood-Brain Barrier for Derivatives of 1,4-Benzodiazepine". Neurophysiology 46 (3): 199–205. ISSN 0090-2977. doi:10.1007/s11062-014-9429-2. 



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