Open Access Articles- Top Results for 5-(Nonyloxy)tryptamine


Systematic (IUPAC) name
Clinical data
157798-12-4 7pxY
PubChem CID 1797
Chemical data
Formula C19H30N2O
302.453 g/mol
 14pxY (what is this?)  (verify)

5-(Nonyloxy)tryptamine is a tryptamine derivative which acts as a selective agonist at the 5-HT1B receptor. Increasing the O-alkoxy chain length in this series gives generally increasing potency and selectivity for 5-HT1B, with highest activity found for the nonyloxy derivative, having a 5-HT1B binding affinity of 1.0 nM, and around 300-fold selectivity over the related 5-HT1A receptor.[1][2]

See also


  1. ^ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (September 1994). "5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist". Journal of Medicinal Chemistry 37 (18): 2828–30. PMID 8071931. doi:10.1021/jm00044a001. 
  2. ^ Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C (January 1996). "Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors". Journal of Medicinal Chemistry 39 (1): 314–22. PMID 8568822. doi:10.1021/jm950498t. 

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