Open Access Articles- Top Results for 5-Fluoro-DMT


Systematic (IUPAC) name
Clinical data
22120-36-1 7pxN
PubChem CID 2762738
ChemSpider 2043436 7pxY
Chemical data
Formula C12H15FN2
206.259 g/mol
 14pxN (what is this?)  (verify)

5-Fluoro-N,N-dimethyltryptamine (5-fluoro-DMT) is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT. Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT2A/C receptor affinity or intrinsic activity, although 6-fluoro-DET is inactive as a psychedelic despite acting as a 5-HT2A agonist (cf. lisuride), while 4-fluoro-5-methoxy-DMT is a much stronger agonist at 5-HT1A than 5-HT2A.[1][2]

See also


  1. ^ Blair, JB; Kurrasch-Orbaugh, D; Marona-Lewicka, D; Cumbay, MG; Watts, VJ; Barker, EL; Nichols, DE (2000). "Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines". Journal of Medicinal Chemistry 43 (24): 4701–10. PMID 11101361. doi:10.1021/jm000339w. 
  2. ^ Rabin, RA; Regina, M; Doat, M; Winter, JC (2002). "5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens". Pharmacology, Biochemistry, and Behavior 72 (1–2): 29–37. PMID 11900766. doi:10.1016/S0091-3057(01)00720-1. 

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