Open Access Articles- Top Results for 5-IAI


Systematic (IUPAC) name
Clinical data
  •  ?
  • Uncontrolled
Oral, Insufflated, Rectal
132367-76-1 7pxN
PubChem CID 131506
ChemSpider 116224 7pxY
UNII 7X16E45Y1X 7pxY
Chemical data
Formula C9H10IN
259.087 g/mol
 14pxN (what is this?)  (verify)

5-Iodo-2-aminoindane (5-IAI) is a drug which acts as a releasing agent of serotonin, norepinephrine, and dopamine.[1] It was developed in the 1990s by a team led by David E. Nichols at Purdue University.[2] 5-IAI fully substitutes for MDMA in rodents and is a putative entactogen in humans.[2] Unlike related aminoindane derivatives like MDAI and MMAI, 5-IAI causes some serotonergic neurotoxicity in rats, but is substantially less toxic than its corresponding amphetamine homologue pIA, with the damage observed barely reaching statistical significance.[1]

See also


  1. 1.0 1.1 Johnson MP, Conarty PF, Nichols DE (July 1991). "[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology 200 (1): 9–16. PMID 1685125. doi:10.1016/0014-2999(91)90659-E. 
  2. 2.0 2.1 Nichols DE, Johnson MP, Oberlender R (January 1991). "5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine". Pharmacology, Biochemistry, and Behavior 38 (1): 135–9. PMID 1826785. doi:10.1016/0091-3057(91)90601-W. 

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