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Open Access Articles- Top Results for 5-MeO-2-TMT

5-MeO-2-TMT

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5-MeO-2-TMT
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Systematic (IUPAC) name
2-(5-methoxy-2-methyl-H-indol-3-yl)-N,N-dimethylethanamine
Clinical data
Identifiers
67292-68-6
PubChem CID 49756
ChemSpider 45143 7pxY
ChEMBL CHEMBL7143 7pxY
Chemical data
Formula C14H20N2O
232.321 g/mol
 14pxY (what is this?)  (verify)

5-Methoxy-2,N,N-trimethyltryptamine (5-MeO-2,N,N-TMT, 5-MeO-TMT) is a psychoactive drug of the tryptamine chemical class which acts as a psychedelic. It was first synthesized by Alexander Shulgin and reported in his book TiHKAL ("Tryptamines i Have Known And Loved").[1] 5-MeO-TMT is claimed to show psychoactive effects at a dosage of 75-150 mg orally, but these are relatively mild compared to those of other similar compounds. This suggests that while the methyl group on the 2-position of the molecule has impaired the binding of metabolic enzymes like monoamine oxidase (MAO), it is also interfering with binding to and/or activation of the serotonin 5-HT2A receptor, the target responsible for mediating the hallucinogenic effects of such compounds.

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