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Open Access Articles- Top Results for 7-Chlorokynurenic acid

7-Chlorokynurenic acid

7-Chlorokynurenic acid
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IUPAC name
7-Chloro-4-hydroxy-2-quinolinecarboxylic acid
Other names
7-CTKA
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ChemSpider 1813
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C10H6ClNO3
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

7-Chlorokynurenic acid (7-CKA) is a glycine site NMDA receptor antagonist with antidepressant activity in rats.[1][2] Also potently inhibits the uptake of glutamate into synaptic vesicles via competitive blockade of vesicular glutamate transporters.[citation needed]

See also

References

  1. ^ Kemp, JA; Foster, AC; Leeson, PD; Priestley, T; Tridgett, R; Iversen, LL; Woodruff, GN (1988). "7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex". Proceedings of the National Academy of Sciences of the United States of America 85 (17): 6547–6550. PMC 282010. PMID 2842779. doi:10.1073/pnas.85.17.6547. 
  2. ^ Zhu, WL; Wang, SJ; Liu, MM; Shi, HS; Zhang, RX; Liu, JF; Ding, ZB; Lu, L (2013). "Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats". Journal of psychiatry & neuroscience : JPN 38 (5): 306–16. PMC 3756114. PMID 23611177. doi:10.1503/jpn.120228. 


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