Open Access Articles- Top Results for 8-Phenyltheophylline


Skeletal formula of 8-phenyltheophylline
Ball-and-stick model of the 8-phenyltheophylline molecule
Systematic (IUPAC) name
Clinical data
961-45-5 7pxN
PubChem CID 1922
ChemSpider 1846 7pxY
Chemical data
Formula C13H12N4O2
256.259 g/mol
 14pxN (what is this?)  (verify)

8-Phenyltheophylline (8-Phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A1 and A2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor.[1][2][3] It has stimulant effects in animals with similar potency to caffeine.[4] Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2.[5]

See also


  1. ^ Scotini E, Carpenedo F, Fassina G (February 1983). "New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities". Pharmacological Research Communications 15 (2): 131–43. PMID 6844374. doi:10.1016/s0031-6989(83)80055-1. 
  2. ^ Rabe KF, Magnussen H, Dent G (April 1995). "Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants". European Respiratory Journal 8 (4): 637–42. PMID 7664866. 
  3. ^ Howell LL, Morse WH, Spealman RD (September 1990). "Respiratory effects of xanthines and adenosine analogs in rhesus monkeys". The Journal of Pharmacology and Experimental Therapeutics 254 (3): 786–91. PMID 2395111. 
  4. ^ Spealman RD (1988). "Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism". Psychopharmacology 95 (1): 19–24. PMID 3133696. doi:10.1007/bf00212759. 
  5. ^ Murray S, Odupitan AO, Murray BP, Boobis AR, Edwards RJ (March 2001). "Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline". Xenobiotica 31 (3): 135–51. PMID 11465391. doi:10.1080/00498250110043292. 

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