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ABHD6

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolABHD6
External IDsMGI1913332 HomoloGene23246 ChEMBL: 5010 GeneCards: ABHD6 Gene
EC number3.1.1.23
Orthologs
SpeciesHumanMouse
Entrez5740666082
EnsemblENSG00000163686ENSMUSG00000025277
UniProtQ9BV23Q8R2Y0
RefSeq (mRNA)NM_020676NM_025341
RefSeq (protein)NP_065727NP_079617
Location (UCSC)Chr 3:
58.22 – 58.28 Mb
Chr 14:
8 – 8.06 Mb
PubMed search[1][2]

Monoacylglycerol lipase ABHD6 also known as abhydrolase domain-containing protein 6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 gene.

Function

ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of tumours.[1]

ABHD6 has been linked to the endocannabinoid system as it controls the accumulation of 2-AG at the cannabinoid receptors.[2]

Alongside MAGL and ABHD12, ABHD6 controls 99% of 2-AG signalling in the brain.[3]

References

  1. ^ Li F, Fei X, Xu J, Ji C (April 2009). "An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines". Mol. Biol. Rep. 36 (4): 691–6. PMID 18360779. doi:10.1007/s11033-008-9230-7. 
  2. ^ Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N (August 2010). "The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors". Nat. Neurosci. 13 (8): 951–7. PMC 2970523. PMID 20657592. doi:10.1038/nn.2601. 
  3. ^ Savinainen JR, Saario SM, Laitinen JT (February 2012). "The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors". Acta Physiol (Oxf) 204 (2): 267–76. PMC 3320662. PMID 21418147. doi:10.1111/j.1748-1716.2011.02280.x. 



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