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Open Access Articles- Top Results for ACCN2

ACCN2

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Identifiers
SymbolsASIC1 ; ACCN2; ASIC; BNaC2
External IDsOMIM602866 MGI1194915 HomoloGene121755 IUPHAR: 684 ChEMBL: 1628477 GeneCards: ASIC1 Gene
RNA expression pattern
File:PBB GE ACCN2 37953 s at tn.png
File:PBB GE ACCN2 205156 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez4111419
EnsemblENSG00000110881ENSMUSG00000023017
UniProtP78348Q6NXK8
RefSeq (mRNA)NM_001095NM_001289791
RefSeq (protein)NP_001086NP_001276720
Location (UCSC)Chr 12:
50.45 – 50.48 Mb
Chr 15:
99.67 – 99.7 Mb
PubMed search[1][2]

Amiloride-sensitive cation channel 2, neuronal is a protein that in humans is encoded by the ACCN2 gene.[1][2]

Function

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.[2]

Interactions

ACCN2 has been shown to interact with PICK1.[3][4]

See also

References

Further reading

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