Open Access Articles- Top Results for ACVR1B


External IDsOMIM601300 MGI1338944 HomoloGene20906 IUPHAR: 1787 ChEMBL: 5310 GeneCards: ACVR1B Gene
EC number2.7.11.30
RefSeq (mRNA)NM_004302NM_007395
RefSeq (protein)NP_004293NP_031421
Location (UCSC)Chr 12:
52.35 – 52.39 Mb
Chr 15:
101.17 – 101.21 Mb
PubMed search[1][2]

Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene.[1][2]

ACVR1B or ALK-4 acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.[3] ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto.[4]


Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.[2]


ACVR1B has been shown to interact with


  1. ^ ten Dijke P, Ichijo H, Franzén P, Schulz P, Saras J, Toyoshima H et al. (October 1993). "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity". Oncogene 8 (10): 2879–87. PMID 8397373. 
  2. ^ a b "Entrez Gene: ACVR1B activin A receptor, type IB". 
  3. ^ Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD et al. (2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74. PMID 12065756. doi:10.1124/mol.62.1.65. 
  4. ^ Harrison CA, Gray PC, Koerber SC, Fischer W, Vale W (2003). "Identification of a functional binding site for activin on the type I receptor ALK4". J. Biol. Chem. 278 (23): 21129–35. PMID 12665502. doi:10.1074/jbc.M302015200. 
  5. ^ a b De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H et al. (May 1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". Exp. Cell Res. 224 (2): 323–34. PMID 8612709. doi:10.1006/excr.1996.0142. 
  6. ^ Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor signaling". Mol. Endocrinol. 13 (1): 15–23. PMID 9892009. doi:10.1210/mend.13.1.0218. 
  7. ^ Attisano L, Wrana JL, Montalvo E, Massagué J (March 1996). "Activation of signalling by the activin receptor complex". Mol. Cell. Biol. 16 (3): 1066–73. PMC 231089. PMID 8622651. 

Further reading