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ADAM11

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Identifiers
SymbolsADAM11 ; MDC
External IDsOMIM155120 MGI1098667 HomoloGene7614 IUPHAR: 1659 GeneCards: ADAM11 Gene
RNA expression pattern
File:PBB GE ADAM11 207880 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez418511488
EnsemblENSG00000073670ENSMUSG00000020926
UniProtO75078Q9R1V4
RefSeq (mRNA)NM_002390NM_001110778
RefSeq (protein)NP_002381NP_001104248
Location (UCSC)Chr 17:
42.84 – 42.86 Mb
Chr 11:
102.76 – 102.78 Mb
PubMed search[1][2]

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.[1][2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.[2]

References

  1. ^ Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet 5 (2): 151–7. PMID 8252040. doi:10.1038/ng1093-151. 
  2. ^ a b "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11". 

Further reading

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External links

  • The MEROPS online database for peptidases and their inhibitors: M12.976
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