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Open Access Articles- Top Results for ADAM18

ADAM18

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Identifiers
SymbolsADAM18 ; ADAM27; tMDCIII
External IDsMGI105986 HomoloGene74941 IUPHAR: 1663 GeneCards: ADAM18 Gene
RNA expression pattern
File:PBB GE ADAM18 207597 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez874913524
EnsemblENSG00000168619ENSMUSG00000031552
UniProtQ9Y3Q7Q9R157
RefSeq (mRNA)NM_001190956NM_010084
RefSeq (protein)NP_001177885NP_034214
Location (UCSC)Chr 8:
39.44 – 39.59 Mb
Chr 8:
24.6 – 24.67 Mb
PubMed search[1][2]

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[1][2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[2]

References

  1. Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod 8 (9): 817–22. PMID 12200459. doi:10.1093/molehr/8.9.817. 
  2. 2.0 2.1 "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18". 

Further reading

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External links

  • The MEROPS online database for peptidases and their inhibitors: M12.957


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