Open Access Articles- Top Results for ADAM19


External IDsOMIM603640 MGI105377 HomoloGene74925 IUPHAR: 1664 GeneCards: ADAM19 Gene
RNA expression pattern
File:PBB GE ADAM19 209765 at tn.png
More reference expression data
RefSeq (mRNA)NM_023038NM_001291890
RefSeq (protein)NP_150377NP_001278819
Location (UCSC)Chr 5:
156.82 – 157 Mb
Chr 11:
46.06 – 46.15 Mb
PubMed search[1][2]

ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.[1]


This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.[1]


ADAM19 has been shown to interact with ABI2.[2]


  1. 1.0 1.1 "Entrez Gene: ADAM19 ADAM metallopeptidase domain 19 (meltrin beta)". 
  2. Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (Sep 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Molecular Biology Reports 29 (3): 317–23. PMID 12463424. doi:10.1023/A:1020409217215. 

Further reading

  • Adams MD, Kerlavage AR, Fields C, Venter JC (Jul 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nature Genetics 4 (3): 256–67. PMID 8358434. doi:10.1038/ng0793-256. 
  • Inoue D, Reid M, Lum L, Krätzschmar J, Weskamp G, Myung YM et al. (Feb 1998). "Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells". The Journal of Biological Chemistry 273 (7): 4180–7. PMID 9461614. doi:10.1074/jbc.273.7.4180. 
  • Hirohata S, Seldin MF, Apte SS (Nov 1998). "Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11". Genomics 54 (1): 178–9. PMID 9806848. doi:10.1006/geno.1998.5544. 
  • Fritsche J, Moser M, Faust S, Peuker A, Büttner R, Andreesen R et al. (Jul 2000). "Molecular cloning and characterization of a human metalloprotease disintegrin--a novel marker for dendritic cell differentiation". Blood 96 (2): 732–9. PMID 10887142. 
  • Shirakabe K, Wakatsuki S, Kurisaki T, Fujisawa-Sehara A (Mar 2001). "Roles of Meltrin beta /ADAM19 in the processing of neuregulin". The Journal of Biological Chemistry 276 (12): 9352–8. PMID 11116142. doi:10.1074/jbc.M007913200. 
  • Wei P, Zhao YG, Zhuang L, Ruben S, Sang QX (Jan 2001). "Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta". Biochemical and Biophysical Research Communications 280 (3): 744–55. PMID 11162584. doi:10.1006/bbrc.2000.4200. 
  • Zhao YG, Wei P, Sang QX (Nov 2001). "Inhibitory antibodies against endopeptidase activity of human adamalysin 19". Biochemical and Biophysical Research Communications 289 (1): 288–94. PMID 11708814. doi:10.1006/bbrc.2001.5958. 
  • Kang T, Zhao YG, Pei D, Sucic JF, Sang QX (Jul 2002). "Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites". The Journal of Biological Chemistry 277 (28): 25583–91. PMID 12006600. doi:10.1074/jbc.M203532200. 
  • Díaz-Rodríguez E, Montero JC, Esparís-Ogando A, Yuste L, Pandiella A (Jun 2002). "Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding". Molecular Biology of the Cell 13 (6): 2031–44. PMC 117622. PMID 12058067. doi:10.1091/mbc.01-11-0561. 
  • Kang T, Park HI, Suh Y, Zhao YG, Tschesche H, Sang QX (Dec 2002). "Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity". The Journal of Biological Chemistry 277 (50): 48514–22. PMID 12393862. doi:10.1074/jbc.M208961200. 
  • Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (Sep 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Molecular Biology Reports 29 (3): 317–23. PMID 12463424. doi:10.1023/A:1020409217215. 
  • Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM et al. (May 2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". The Journal of Biological Chemistry 278 (19): 16844–51. PMID 12615925. doi:10.1074/jbc.M300267200. 
  • Chesneau V, Becherer JD, Zheng Y, Erdjument-Bromage H, Tempst P, Blobel CP (Jun 2003). "Catalytic properties of ADAM19". The Journal of Biological Chemistry 278 (25): 22331–40. PMID 12682046. doi:10.1074/jbc.M302781200. 
  • Kang T, Tschesche H, Amy Sang QX (Aug 2004). "Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19". Experimental Cell Research 298 (1): 285–95. PMID 15242783. doi:10.1016/j.yexcr.2004.04.022. 
  • Ehrnsperger A, Rehli M, Thu-Hang P, Kreutz M (Jul 2005). "Epigenetic regulation of the dendritic cell-marker gene ADAM19". Biochemical and Biophysical Research Communications 332 (2): 456–64. PMID 15896713. doi:10.1016/j.bbrc.2005.04.149. 
  • Melenhorst WB, van den Heuvel MC, Stegeman CA, van der Leij J, Huitema S, van den Berg A et al. (Jul 2006). "Upregulation of ADAM19 in chronic allograft nephropathy". American Journal of Transplantation 6 (7): 1673–81. PMID 16827870. doi:10.1111/j.1600-6143.2006.01384.x. 
  • Tanabe C, Hotoda N, Sasagawa N, Sehara-Fujisawa A, Maruyama K, Ishiura S (Jan 2007). "ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells". Biochemical and Biophysical Research Communications 352 (1): 111–7. PMID 17112471. doi:10.1016/j.bbrc.2006.10.181. 

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