Open Access Articles- Top Results for ADAM22


SymbolsADAM22 ; ADAM 22; MDC2
External IDsOMIM603709 MGI1340046 HomoloGene37898 IUPHAR: 1667 GeneCards: ADAM22 Gene
RNA expression pattern
File:PBB GE ADAM22 206615 s at tn.png
File:PBB GE ADAM22 206616 s at tn.png
File:PBB GE ADAM22 208226 x at tn.png
More reference expression data
RefSeq (mRNA)NM_004194NM_001007220
RefSeq (protein)NP_004185NP_001007221
Location (UCSC)Chr 7:
87.56 – 87.83 Mb
Chr 5:
8.07 – 8.37 Mb
PubMed search[1][2]

Disintegrin and metalloproteinase domain-containing protein 22 also known as ADAM22 is an enzyme that in humans is encoded by the ADAM22 gene.[1][2][3]


ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants.[3]


ADAM22 has been shown to interact with DLG4.[4]


  1. ^ Sagane K, Ohya Y, Hasegawa Y, Tanaka I (Oct 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". Biochem J. 334 ( Pt 1) (Pt 1): 93–8. PMC 1219666. PMID 9693107. 
  2. ^ Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (Nov 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene 237 (1): 61–70. PMID 10524237. doi:10.1016/S0378-1119(99)00302-9. 
  3. ^ a b "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22". 
  4. ^ Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (September 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science 313 (5794): 1792–5. PMID 16990550. doi:10.1126/science.1129947. 

Further reading


External links

  • The MEROPS online database for peptidases and their inhibitors: M12.978

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