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Open Access Articles- Top Results for ADAMTS10

ADAMTS10

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Identifiers
SymbolsADAMTS10 ; ADAM-TS10; ADAMTS-10; WMS; WMS1
External IDsOMIM608990 MGI2449112 HomoloGene81940 IUPHAR: 1683 GeneCards: ADAMTS10 Gene
RNA expression pattern
File:PBB GE ADAMTS10 gnf1h03448 at tn.png
File:PBB GE ADAMTS10 gnf1h03449 s at tn.png
File:PBB GE ADAMTS10 gnf1h03450 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez81794224697
EnsemblENSG00000142303ENSMUSG00000024299
UniProtQ9H324P58459
RefSeq (mRNA)NM_001282352NM_172619
RefSeq (protein)NP_001269281NP_766207
Location (UCSC)Chr 19:
8.65 – 8.68 Mb
Chr 17:
33.52 – 33.55 Mb
PubMed search[1][2]

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.[1]

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[1]

References

Further reading

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External links

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