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Open Access Articles- Top Results for ADAMTS5

ADAMTS5

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Identifiers
SymbolsADAMTS5 ; ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADMP-2
External IDsOMIM605007 MGI1346321 HomoloGene5109 IUPHAR: 1678 ChEMBL: 2285 GeneCards: ADAMTS5 Gene
EC number3.4.24.-
Orthologs
SpeciesHumanMouse
Entrez1109623794
EnsemblENSG00000154736ENSMUSG00000022894
UniProtQ9UNA0Q9R001
RefSeq (mRNA)NM_007038NM_011782
RefSeq (protein)NP_008969NP_035912
Location (UCSC)Chr 21:
28.29 – 28.34 Mb
Chr 16:
85.86 – 85.9 Mb
PubMed search[1][2]

A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene.[1][2]

Function

ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.[3]

Clinical significance

Genetically modified mice in which the catalytic domain of ADAMTS5 was deleted are resistant to cartilage destruction in an experimental model of osteoarthritis.[4] ADAMTS5 is the major aggrecanase in mouse cartilage in a mouse model of inflammatory arthritis.[5]

References

  1. Abbaszade I, Liu RQ, Yang F, Rosenfeld SA, Ross OH, Link JR, Ellis DM, Tortorella MD, Pratta MA, Hollis JM, Wynn R, Duke JL, George HJ, Hillman MC, Murphy K, Wiswall BH, Copeland RA, Decicco CP, Bruckner R, Nagase H, Itoh Y, Newton RC, Magolda RL, Trzaskos JM, Burn TC (August 1999). "Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family". J. Biol. Chem. 274 (33): 23443–50. PMID 10438522. doi:10.1074/jbc.274.33.23443. 
  2. Hurskainen TL, Hirohata S, Seldin MF, Apte SS (September 1999). "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family". J. Biol. Chem. 274 (36): 25555–63. PMID 10464288. doi:10.1074/jbc.274.36.25555. 
  3. "Entrez Gene: ADAM metallopeptidase with thrombospondin type 1 motif". 
  4. Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, Flannery CR, Peluso D, Kanki K, Yang Z, Majumdar MK, Morris EA (March 2005). "Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis". Nature 434 (7033): 644–8. PMID 15800624. doi:10.1038/nature03369. 
  5. Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ (March 2005). "ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro". Nature 434 (7033): 648–52. PMID 15800625. doi:10.1038/nature03417. 

Further reading

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External links


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