|Classification and external resources|
|Specialty||Hematology and oncology|
|Patient UK||AIDS-related lymphoma|
A lymphoma is a type of cancer arising from lymphoid cells. In AIDS, the incidences of non-Hodgkin's lymphoma, primary cerebral lymphoma and Hodgkin's disease are all increased. There are three different varieties of AIDS-related lymphoma: Diffuse large B-cell lymphoma, B-cell immunoblastic lymphoma, and Burkitt's lymphoma (small non-cleaved cell lymphoma).
The symptoms of AIDS-related lymphoma can include: weight loss, fever, and night sweats.
Non-Hodgkin's lymphoma (NHL) is present in about 1-3% of HIV seropositive people at the time of the initial diagnosis of HIV. However, it is believed that such patients have been seropositive for a prolonged period, but have simply not had their infections recognized previously. This is so because immunodysregulation must exist for an extended interval of time, in order for a lymphoproliferative process to evolve in that context.
Primary cerebral lymphoma
Primary cerebral lymphoma (or primary central nervous system lymphoma) is a form of NHL. It is very rare in immunocompetent people, with an incidence of 5–30 cases per million person-years. However the incidence in immunocompromised individuals is greatly increased, up to 100 per million person-years.
Treatment of AIDS patients with antiretroviral drugs reduces the incidence of primary cerebral lymphoma.
The incidence of Hodgkin's disease in the general population is about 10–30 per million person-years. This increases to 170 per million person-years in HIV positive patients.
- Besson C, Goubar A, Gabarre J et al. (October 2001). "Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy". Blood 98 (8): 2339–44. PMID 11588028. doi:10.1182/blood.V98.8.2339.
- Rigolet A, Bossi P, Caumes E et al. (September 2001). "Caractéristiques épidémiologiques et évolution de l'incidence des lymphomes cérébraux primitifs observés chez 80 patients infectés par le VIH entre 1983 et 1999" [Epidemiological features and incidence trends of primary cerebral lymphomas observed in 80 HIV-infected patients from 1983 to 1999]. Pathologie-biologie (in French) 49 (7): 572–5. PMID 11642021. doi:10.1016/S0369-8114(01)00206-1.
- "AIDS-Related Lymphoma Treatment (PDQ®) - National Cancer Institute". Cancer.gov. 2012-05-18. Retrieved 2012-05-30.
- Tran H, Nourse J, Hall S, Green M, Griffiths L, Gandhi MK. Immunodeficiency-associated lymphomas. Blood Rev 2008 Sep;22(5):261-281.
- Grulich AE, Wan X, Law MG, Milliken ST, Lewis CR, Garsia RJ, Gold J, Finlayson RJ, Cooper DA, Kaldor JM. B-cell stimulation and prolonged immune deficiency are risk factors for non-Hodgkin's lymphoma in people with AIDS. AIDS 2000 Jan 28;14(2):133-140.
- "Primary lymphoma of the brain: MedlinePlus Medical Encyclopedia". Nlm.nih.gov. Retrieved 2012-05-30.
- Office of HIV and AIDS Malignancy in the National Cancer Institute
- Information on AIDS-related cancers from the National Cancer Institute