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ALDH1A2

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Identifiers
SymbolsALDH1A2 ; RALDH(II); RALDH2; RALDH2-T
External IDsOMIM603687 MGI107928 HomoloGene68368 GeneCards: ALDH1A2 Gene
EC number1.2.1.36
Orthologs
SpeciesHumanMouse
Entrez885419378
EnsemblENSG00000128918ENSMUSG00000013584
UniProtO94788Q62148
RefSeq (mRNA)NM_001206897NM_009022
RefSeq (protein)NP_001193826NP_033048
Location (UCSC)Chr 15:
58.25 – 58.79 Mb
Chr 9:
71.22 – 71.3 Mb
PubMed search[1][2]

Retinaldehyde dehydrogenase 2 (RALDH2) is an enzyme that in humans is encoded by the ALDH1A2 gene.[1][2]

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a paracrine hormone signaling molecule that functions in developing and adult tissues.[3] The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels that facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.[2]

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