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ALDH1L1

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Identifiers
SymbolsALDH1L1 ; 10-FTHFDH; 10-fTHF; FDH; FTHFD
External IDsOMIM600249 MGI1340024 HomoloGene122031 GeneCards: ALDH1L1 Gene
EC number1.5.1.6
RNA expression pattern
File:PBB GE ALDH1L1 205208 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez10840107747
EnsemblENSG00000144908ENSMUSG00000030088
UniProtO75891Q8R0Y6
RefSeq (mRNA)NM_001270364NM_027406
RefSeq (protein)NP_001257293NP_081682
Location (UCSC)Chr 3:
125.82 – 125.92 Mb
Chr 6:
90.49 – 90.6 Mb
PubMed search[1][2]

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.[1]

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.[1]

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Further reading

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