Open Access Articles- Top Results for AM-855


Systematic (IUPAC) name
Clinical data
PubChem CID 10091328
ChemSpider 8266865 7pxY
ChEMBL CHEMBL303479 7pxY
Chemical data
Formula C26H38O2
382.577 g/mol
 14pxY (what is this?)  (verify)

AM-855 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8Tetrahydrocannabinol with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 22.3nM at CB1 and 58.6nM at CB2.[1]


  1. ^ Khanolkara, Atmaram D.; Lua, Dai; Fana, Pusheng; Tiana, Xiaoyu; Makriyannis, Alexandros (August 1999). "Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol". Bioorganic & Medicinal Chemistry Letters 9 (15): 2119–24. PMID 10465529. doi:10.1016/S0960-894X(99)00355-8. 

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