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Open Access Articles- Top Results for AMG-1

AMG-1

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AMG-1
240px
Systematic (IUPAC) name
(6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Clinical data
Identifiers
 7pxY
PubChem CID 10830874
ChemSpider 9006174 7pxY
ChEMBL CHEMBL279147 7pxY
Chemical data
Formula C23H30O2
338.482 g/mol
 14pxY (what is this?)  (verify)

AMG-1 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6nM at CB1 vs 3.1nM at CB2.[1]


References

  1. ^ Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753

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