Open Access Articles- Top Results for AMG-36


Systematic (IUPAC) name
Clinical data
PubChem CID 10982174
ChemSpider 9157375 7pxY
ChEMBL CHEMBL108868 7pxY
Chemical data
Formula C27H40O2
396.604 g/mol
 14pxY (what is this?)  (verify)

AMG-36 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.4nM at CB1 vs 1.9nM at CB2.[1][2]


  1. ^ Papahatjis DP, et al. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
  2. ^ Papahatjis DP, et al. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. PMID 17672444

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