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ARAF

For other meanings, see Araf (disambiguation).
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Identifiers
SymbolsARAF ; A-RAF; ARAF1; PKS2; RAFA1
External IDsOMIM311010 MGI88065 HomoloGene1249 IUPHAR: 1933 ChEMBL: 1169596 GeneCards: ARAF Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE ARAF 201895 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez36911836
EnsemblENSG00000078061ENSMUSG00000001127
UniProtP10398P04627
RefSeq (mRNA)NM_001256196NM_001159645
RefSeq (protein)NP_001243125NP_001153117
Location (UCSC)Chr X:
47.42 – 47.43 Mb
Chr X:
20.8 – 20.86 Mb
PubMed search[1][2]

Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene.[1] A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases.[2]

Interactions

ARAF has been shown to interact with:

References

  1. ^ "Entrez Gene: ARAF V-raf murine sarcoma 3611 viral oncogene homolog". 
  2. ^ Mark GE, Seeley TW, Shows TB, Mountz JD (September 1986). "Pks, a raf-related sequence in humans". Proc. Natl. Acad. Sci. U.S.A. 83 (17): 6312–6. PMC 386493. PMID 3529082. doi:10.1073/pnas.83.17.6312. 
  3. ^ a b c d e Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics 81 (2): 112–25. PMID 12620389. doi:10.1016/S0888-7543(02)00008-3. 
  4. ^ Yin XL, Chen S, Yan J, Hu Y, Gu JX (February 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta 1589 (1): 71–6. PMID 11909642. doi:10.1016/S0167-4889(01)00188-4. 
  5. ^ a b c Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. PMC 85938. PMID 10848612. doi:10.1128/MCB.20.13.4870-4878.2000. 
  6. ^ Yin XL, Chen S, Gu JX (February 2002). "Identification of TH1 as an interaction partner of A-Raf kinase". Mol. Cell. Biochem. 231 (1–2): 69–74. PMID 11952167. doi:10.1023/A:1014437024129. 

Further reading

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