ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1, is a protein that in humans is encoded by the ARL13B gene.
This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia  and plays a role in cilia formation and in maintenance of cilia.
Mutations in the ARL13B gene are associated with the Joubert syndrome.
- ^ a b "Entrez Gene: ADP-ribosylation factor-like 13B".
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- ^ Delling, M.; Decaen, P. G.; Doerner, J. F.; Febvay, S.; Clapham, D. E. (2013). "Primary cilia are specialized calcium signalling organelles". Nature 504 (7479): 311–314. PMID 24336288. doi:10.1038/nature12833.
- ^ Decaen, P. G.; Delling, M.; Vien, T. N.; Clapham, D. E. (2013). "Direct recording and molecular identification of the calcium channel of primary cilia". Nature 504 (7479): 315–318. PMID 24336289. doi:10.1038/nature12832.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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