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Open Access Articles- Top Results for AS-8112

AS-8112

AS-8112
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This page is a soft redirect. Names

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IUPAC name
5-bromo-N-[(6R)-1-ethyl-4-methyl-1,4-diazepan-6-yl]-2-methoxy-4-(methylamino)benzamide
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ChemSpider 9168209 7pxY
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This page is a soft redirect. Properties

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C17H27BrN4O2
Molar mass 399.325 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3.[1] It has potent antiemetic effects in animal studies and has been investigated for potential medical use.[2][3]


References

  1. ^ Yoshikawa T, Yoshida N, Oka M (May 2001). "The broad-spectrum anti-emetic activity of AS-8112, a novel dopamine D2, D3 and 5-HT3 receptors antagonist". British Journal of Pharmacology 133 (2): 253–60. PMC 1572785. PMID 11350861. doi:10.1038/sj.bjp.0704078. 
  2. ^ Yoshikawa T, Yoshida N, Oka M (November 2001). "Central antiemetic effects of AS-8112, a dopamine D2, D3, and 5-HT(3) receptor antagonist, in ferrets". European Journal of Pharmacology 431 (3): 361–4. PMID 11730730. doi:10.1016/S0014-2999(01)01459-5. 
  3. ^ Hirokawa Y, Fujiwara I, Suzuki K, Harada H, Yoshikawa T, Yoshida N, Kato S (February 2003). "Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity". Journal of Medicinal Chemistry 46 (5): 702–15. PMID 12593651. doi:10.1021/jm020270n. 


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