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ATF5

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsATF5 ; ATFX; HMFN0395
External IDsOMIM606398 MGI2141857 HomoloGene32142 GeneCards: ATF5 Gene
RNA expression pattern
File:PBB GE ATF5 204998 s at tn.png
File:PBB GE ATF5 204999 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez22809107503
EnsemblENSG00000169136ENSMUSG00000038539
UniProtQ9Y2D1O70191
RefSeq (mRNA)NM_001193646NM_030693
RefSeq (protein)NP_001180575NP_109618
Location (UCSC)Chr 19:
50.43 – 50.44 Mb
Chr 7:
44.81 – 44.82 Mb
PubMed search[1][2]

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.[1]

Function

First described by Nishizawa and Nagata,[2] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.[3][4]

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.

See also

Interactions

ATF5 has been shown to interact with DISC1[5] and TRIB3.[6]

References

  1. ^ "Entrez Gene: ATF5 activating transcription factor 5". 
  2. ^ Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. PMC 84326. PMID 10373550. 
  3. ^ Hai T, Hartman MG (July 2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene 273 (1): 1–11. PMID 11483355. doi:10.1016/S0378-1119(01)00551-0. 
  4. ^ Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M (September 2002). "Classification of human B-ZIP proteins based on dimerization properties". Mol. Cell. Biol. 22 (18): 6321–6335. PMC 135624. PMID 12192032. doi:10.1128/MCB.22.18.6321-6335.2002. 
  5. ^ Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. PMID 12812986. doi:10.1093/hmg/ddg162. 
  6. ^ Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J et al. (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–948. PMID 18276110. doi:10.1016/j.cellsig.2008.01.010. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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