Open Access Articles- Top Results for ATF6


SymbolsATF6 ; ATF6A
External IDsOMIM605537 MGI1926157 HomoloGene32015 GeneCards: ATF6 Gene
RNA expression pattern
File:PBB GE ATF6 203952 at tn.png
File:PBB GE ATF6 217550 at tn.png
More reference expression data
RefSeq (mRNA)NM_007348NM_001081304
RefSeq (protein)NP_031374NP_001074773
Location (UCSC)Chr 1:
161.74 – 161.93 Mb
Chr 1:
170.7 – 170.87 Mb
PubMed search[1][2]

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[1][2][3] and is involved in the unfolded protein response.


ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[4] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also


ATF6 has been shown to interact with YY1[5] and Serum response factor.[2]


  1. Hai TW, Liu F, Coukos WJ, Green MR (December 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. PMID 2516827. doi:10.1101/gad.3.12b.2083. 
  2. 2.0 2.1 Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374. 
  3. Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH et al. (July 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. 92 (7): 2720–5. PMID 17440018. doi:10.1210/jc.2006-2280. 
  4. "Entrez Gene: ATF6 activating transcription factor 6". 
  5. Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S et al. (2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096–106. PMC 85959. PMID 10866666. doi:10.1128/MCB.20.14.5096-5106.2000. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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