Open Access Articles- Top Results for ATOH1


SymbolsATOH1 ; ATH1; HATH1; MATH-1; bHLHa14
External IDsOMIM601461 MGI104654 HomoloGene31297 GeneCards: ATOH1 Gene
RNA expression pattern
File:PBB GE ATOH1 221336 at tn.png
More reference expression data
RefSeq (mRNA)NM_005172NM_007500
RefSeq (protein)NP_005163NP_031526
Location (UCSC)Chr 4:
94.75 – 94.75 Mb
Chr 6:
64.73 – 64.73 Mb
PubMed search[1][2]

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.[1][2]

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.[2] ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal. ATOH1 is considered part of the Notch signaling pathway.

In 2009, ATOH1 was identified as a "cancer switch-off" gene. [3]


  1. ^ Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (Jan 1997). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Hum Mol Genet 5 (9): 1207–16. PMID 8872459. doi:10.1093/hmg/5.9.1207. 
  2. ^ a b "Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)". 

Further reading


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