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ATP1A4

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Identifiers
SymbolsATP1A4 ; ATP1A1; ATP1AL2
External IDsOMIM607321 HomoloGene113769 IUPHAR: 836 ChEMBL: 4053 GeneCards: ATP1A4 Gene
EC number3.6.3.9
RNA expression pattern
File:PBB GE ATP1A4 gnf1h01969 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez48027222
EnsemblENSG00000132681ENSMUSG00000007107
UniProtQ13733Q9WV27
RefSeq (mRNA)NM_001001734NM_013734
RefSeq (protein)NP_001001734NP_038762
Location (UCSC)Chr 1:
160.12 – 160.16 Mb
Chr 1:
172.22 – 172.26 Mb
PubMed search[1][2]

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.[1][2][3]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

References

  1. ^ Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC (May 1991). "A detailed multipoint gene map of chromosome 1q". Genomics 8 (1): 13–21. PMID 1981991. doi:10.1016/0888-7543(90)90220-O. 
  2. ^ Shull MM, Lingrel JB (Jul 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A 84 (12): 4039–43. PMC 305017. PMID 3035563. doi:10.1073/pnas.84.12.4039. 
  3. ^ a b "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide". 

Further reading

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