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ATP2A3

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Identifiers
SymbolsATP2A3 ; SERCA3
External IDsOMIM601929 MGI1194503 HomoloGene69131 IUPHAR: 842 ChEMBL: 2401 GeneCards: ATP2A3 Gene
EC number3.6.3.8
RNA expression pattern
File:PBB GE ATP2A3 207522 s at tn.png
File:PBB GE ATP2A3 207521 s at tn.png
File:PBB GE ATP2A3 213036 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez48953313
EnsemblENSG00000074370ENSMUSG00000020788
UniProtQ93084Q64518
RefSeq (mRNA)NM_005173NM_001163336
RefSeq (protein)NP_005164NP_001156808
Location (UCSC)Chr 17:
3.83 – 3.87 Mb
Chr 11:
72.96 – 72.99 Mb
PubMed search[1][2]

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.[1][2]

This gene encodes one of the SERCA Ca2+-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.[2]

References

  1. ^ Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene". Biochem J 318 (2): 689–99. PMC 1217674. PMID 8809064. 
  2. ^ a b "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous". 

Further reading

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