Open Access Articles- Top Results for ATP6V1G2


SymbolsATP6V1G2 ; ATP6G; ATP6G2; NG38; VMA10
External IDsOMIM606853 MGI1913487 HomoloGene41518 IUPHAR: 820 GeneCards: ATP6V1G2 Gene
EC number3.6.3.14
RefSeq (mRNA)NM_001204078NM_023179
RefSeq (protein)NP_001191007NP_075668
Location (UCSC)Chr 6:
31.51 – 31.52 Mb
Chr 17:
35.23 – 35.24 Mb
PubMed search[1][2]

V-type proton ATPase subunit G 2 is an enzyme that in humans is encoded by the ATP6V1G2 gene.[1][2]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described.[2]


  1. ^ Neville MJ, Campbell RD (May 1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC". J Immunol 162 (8): 4745–54. PMID 10202016. 
  2. ^ a b "Entrez Gene: ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2". 

Further reading


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