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Open Access Articles- Top Results for AXL receptor tyrosine kinase

AXL receptor tyrosine kinase

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Identifiers
SymbolsAXL ; JTK11; UFO
External IDsOMIM109135 MGI1347244 HomoloGene7583 IUPHAR: 1835 ChEMBL: 4895 GeneCards: AXL Gene
EC number2.7.10.1
RNA expression pattern
File:PBB GE AXL 202686 s at tn.png
File:PBB GE AXL 202685 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez55826362
EnsemblENSG00000167601ENSMUSG00000002602
UniProtP30530Q00993
RefSeq (mRNA)NM_001278599NM_001190974
RefSeq (protein)NP_001265528NP_001177903
Location (UCSC)Chr 19:
41.73 – 41.77 Mb
Chr 7:
25.76 – 25.79 Mb
PubMed search[1][2]

Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. [1][2]

Function

The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene, which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.[2]

Interactions

AXL receptor tyrosine kinase has been shown to interact with TENC1.[3] Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.[4]

References

  1. ^ O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R 3rd, Le Beau MM, Earp HS, Liu ET (Oct 1991). "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase". Mol Cell Biol 11 (10): 5016–31. PMC 361494. PMID 1656220. 
  2. ^ a b "Entrez Gene: AXL AXL receptor tyrosine kinase". 
  3. ^ Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. PMID 12470648. doi:10.1016/S0006-291X(02)02718-3. 
  4. ^ Vajkoczy P, Knyazev P, Kunkel A, Capelle HH, Behrndt S, von Tengg-Kobligk H, Kiessling F, Eichelsbacher U, Essig M, Read TA, Erber R, Ullrich A (2006). "Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5799–804. PMC 1458653. PMID 16585512. doi:10.1073/pnas.0510923103. 

Further reading

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