|File:Diseases of Swine 25-5.png|
|Classification and external resources|
|ICD-10||L11.9 (ILDS L11.900)|
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. It is absent in bullous pemphigoid, making it useful for differential diagnosis.