Open Access Articles- Top Results for Acantholysis


Not to be confused with Acanthosis.
File:Diseases of Swine 25-5.png
Foot-and-mouth disease - acantholysis in a sample of a skin vesicle: Necrosis of the stratum spinosum can be observed, and keratinocytes floating in the vesicular fluid (spongiosa).
Classification and external resources
ICD-10 L11.9 (ILDS L11.900)
DiseasesDB 31172
NCI Acantholysis
Patient UK Acantholysis

Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes,[1] seen in diseases such as pemphigus vulgaris.[2] It is absent in bullous pemphigoid, making it useful for differential diagnosis.

This histological feature is also seen in herpes simplex infections (HSV 1 and 2).

See also


  1. Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
  2. Medical Dictionary Entry