Adverts

Open Access Articles- Top Results for Accelerated phase chronic myelogenous leukemia

Accelerated phase chronic myelogenous leukemia

Aman vibhore
Classification and external resources
Specialty Hematology and oncology
NCI Accelerated phase chronic myelogenous leukemia
Patient UK Accelerated phase chronic myelogenous leukemia
MeSH D015465

Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease is progressing.[1] In this phase, 10 to 19 % of the cells in the blood and bone marrow are blast cells (immature blood cells). In the accelerated phase, these leukemia cells grow quickly.

Symptoms

Common symptoms include fever, bone pain, and swollen spleen.[2]

Treatment

Patients treated with imatinib, dasatinib, and nilotinib have shown meaningful rates of hematologic and cytogenetic response.[3]

Prognosis

Prognosis is very poor once chronic myelogenous leukemia reaches the accelerated phase; it behaves similarly to acute myeloid leukemia.

References

  1. ^ Moshe Talpaz (2002). "Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study". Blood 99 (6): 1928–1937. doi:10.1182/blood.v99.6.1928. 
  2. ^ "Chronic myelogenous leukemia (CML)". 
  3. ^ Shah, NP (Mar 2008). "Advanced CML: therapeutic options for patients in accelerated and blast phases.". Journal of the National Comprehensive Cancer Network : JNCCN. 6 Suppl 2: S31–S36. PMID 18397679. 

External links

Lua error in package.lua at line 80: module 'Module:Buffer' not found.