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Aceclofenac

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Aceclofenac
File:Aceclofenac.png
Systematic (IUPAC) name
2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid
Clinical data
Trade names Hifenac, Cincofen, Nacsiv, Acenac
AHFS/Drugs.com International Drug Names
oral, topical
Identifiers
89796-99-6 7pxN
M01AB16 M02AA25
PubChem CID 71771
ChemSpider 64809 7pxY
UNII RPK779R03H 7pxY
KEGG D01545 7pxY
ChEBI CHEBI:31159 7pxN
ChEMBL CHEMBL93645 7pxY
Chemical data
Formula C16H13Cl2NO4
354.18472 g/mol
 14pxN (what is this?)  (verify)

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The dose is 100 mg twice daily.

It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.

Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac.

Synthesis

File:Aceclofenac synthesis.svg
Aceclofenac synthesis.[1]

References

References


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