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Open Access Articles- Top Results for Acemetacin

Acemetacin

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Acemetacin
File:Acemetacin.svg
Systematic (IUPAC) name
2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
53164-05-9 7pxY
M01AB11
PubChem CID 1981
ChemSpider 1904 7pxY
UNII 5V141XK28X 7pxY
KEGG D01582 7pxY
ChEBI CHEBI:31162
ChEMBL CHEMBL189171 7pxY
Chemical data
Formula C21H18ClNO6
415.82372 g/mol
 14pxY (what is this?)  (verify)

Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. It is manufactured by Merck KGaA under the tradename Emflex, and is available in the UK as a prescription-only drug. Other brand names for acemetacin include Rheutrop (Austria), Acemetadoc, Acephlogont, Azeat, Rantudil (Germany, Mexico, Portugal), Gamespir (Greece), Oldan, Reudol (Spain), Tilur (Switzerland), Ost-map (Egypt).

Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.

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