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Open Access Articles- Top Results for Acenocoumarol

Acenocoumarol

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Acenocoumarol
200px
Systematic (IUPAC) name
(RS)-4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
  • X
Oral
Pharmacokinetic data
Metabolism Hepatic
Half-life 8 to 11 hours
Identifiers
152-72-7 7pxY
B01AA07
PubChem CID 9052
DrugBank DB01418 7pxY
ChemSpider 10443441 7pxY
UNII I6WP63U32H 7pxY
KEGG D07064 7pxY
ChEBI CHEBI:53766 7pxY
ChEMBL CHEMBL397420 7pxY
Chemical data
Formula C19H15NO6
353.326 g/mol
 14pxY (what is this?)  (verify)

Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.

Dosage

Research in the RECAVA network has discovered that two acquired factors (age and body mass index) and three genetic polymorphisms (genes VKORC1, CYP2C9 and CYP4F2) are useful to establish the correct dosage. Acenocoumarol is contraindicated during pregnancy.

External links

  • DDB 29202
  • Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673–6. PMID 15613922. doi:10.1097/00001721-200412000-00007. 
  • Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619–21. PMID 15724697. 
  • Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227–46. PMID 16372822. doi:10.2165/00003088-200544120-00003. 
  • Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183–7. PMID 16611310. doi:10.1111/j.1365-2141.2006.06007.x. 

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