Activated protein C resistance
|Activated protein C resistance (APCR)|
|Classification and external resources|
|NCI||Activated protein C resistance|
|Patient UK||Activated protein C resistance|
Activated protein C resistance (APCR) is a hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). This results in an increased risk of venous thrombosis, which can cause problems with circulation, such as pulmonary embolism.
Activated protein C (with protein S as a cofactor) degrades Factor Va and Factor VIIIa. Activated protein C resistance is the inability of protein C to cleave Factor Va and/or Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state. This may be hereditary or acquired. The best known and most common hereditary form is Factor V Leiden. Acquired forms occur in the presence of elevated Factor VIII concentrations.
An estimated 64 percent of patients with venous thromboembolism may have activated protein C resistance.
- Dahlbäck B (2003). "The discovery of activated protein C resistance". J. Thromb. Haemost. 1 (1): 3–9. PMID 12871530. doi:10.1046/j.1538-7836.2003.00016.x.
- Koster T, Rosendaal FR, De Ronde H, Briët E, Vandenbroucke JP, Bertina RM (December 1993). "Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study". Lancet 342 (8886–8887): 1503–6. ISSN 0140-6736. PMID 7902898. doi:10.1016/S0140-6736(05)80081-9.
- Nicolaes GA, Dahlbäck B (2003). "Congenital and acquired activated protein C resistance". Semin Vasc Med 3 (1): 33–46. PMID 15199491. doi:10.1055/s-2003-38331.
- Sheppard DR (2000). "Activated protein C resistance: the most common risk factor for venous thromboembolism". J Am Board Fam Pract 13 (2): 111–5. PMID 10764192. doi:10.3122/15572625-13-2-111.
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