Adverts

Open Access Articles- Top Results for Acute myeloblastic leukemia with maturation

Acute myeloblastic leukemia with maturation

Acute myeloblastic leukemia with maturation
File:Myeloblast.png
Classification and external resources
Specialty Hematology and oncology
ICD-O M9874/3
NCI Acute myeloblastic leukemia with maturation
Patient UK Acute myeloblastic leukemia with maturation
MeSH D015470

M2 is a subtype of AML (Acute Myeloid Leukemia).

It is also known as "Acute Myeloblastic Leukemia with Maturation".[1]

Cause

This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).[2] On both sides of the splice the DNA coded for different proteins, RUNX1 and ETO, These two sequences are then transcribed and translated into a single large protein, "M2 AML" which allows the cell to divide unchecked, leading to cancer.

References

  1. ^ "Acute Myeloid Leukemia - Signs and Symptoms". 
  2. ^ Taj AS, Ross FM, Vickers M et al. (1995). "t(8;21) myelodysplasia, an early presentation of M2 AML". Br. J. Haematol. 89 (4): 890–2. PMID 7772527. doi:10.1111/j.1365-2141.1995.tb08429.x. 

External links

Lua error in package.lua at line 80: module 'Module:Buffer' not found.