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Open Access Articles- Top Results for Adecatumumab

Adecatumumab

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Adecatumumab?
Monoclonal antibody
Type Whole antibody
Source Human
Target EpCAM
Clinical data
Identifiers
503605-66-1 7pxN
None
Chemical data
Formula C6552H10080N1740O2052S46
147.5 kDa
 14pxN (what is this?)  (verify)

Adecatumumab (MT201) is a recombinant human monoclonal antibody which is used to target tumor cells. It binds to the epithelial cell adhesion molecule (EpCAM - CD326).

Adecatumumab has been used in clinical studies of treatment in prostate[1] and breast cancers.[2]

References

  1. ^ Oberneder R, Weckermann D, Ebner B et al. (October 2006). "A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients". Eur. J. Cancer 42 (15): 2530–8. PMID 16930989. doi:10.1016/j.ejca.2006.05.029. 
  2. ^ Prang N, Preithner S, Brischwein K et al. (January 2005). "Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". Br. J. Cancer 92 (2): 342–9. PMC 2361858. PMID 15655555. doi:10.1038/sj.bjc.6602310. 


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