Open Access Articles- Top Results for Almitrine


Skeletal formula of almitrine
Ball-and-stick model of the almitrine molecule
Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
27469-53-0 7pxY
PubChem CID 33887
DrugBank DB01430 7pxY
ChemSpider 31235 7pxY
UNII 9A1222NBG4 7pxY
KEGG D07126 7pxY
ChEBI CHEBI:53778 7pxY
ChEMBL CHEMBL1183717 7pxN
Chemical data
Formula C26H29F2N7
477.552 g/mol
Physical data
Melting point Script error: No such module "convert".
 14pxN (what is this?)  (verify)

Almitrine (marketed as Duxil by Servier) is a diphenylmethylpiperazine derivative classified as a respiratory stimulant by the ATC. It enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep. A significant literature exists for this compound, including over 60 papers that Medline labels as reviews.

The clinical efficacy of almitrine-raubasine combination therapy for age related cerebral disorders and functional rehabilitation after stroke has been reviewed by Allain and Bentué-Ferrer.[1] They summarize two studies in which almitrine-raubasine improved some symptoms significantly more than placebo, especially in vascular cases. Their paper also suggests that other studies have shown a beneficial effect of this compound on neurosensory vascular disorders, specifically chorioretinal dysfunctions (visual symptomatology) and vertigo associated with electronystagmographic modifications. This paper further claims that the dosage and tolerance of the compound have been confirmed in a French multi-center study of 5,361 outpatients.


See also


  1. ^ Allain, H.; Bentué-Ferrer, D. (1998). "Clinical Efficacy of Almitrine-Raubasine". European Neurology 39 (Suppl. 1): 39–44. PMID 9516074. doi:10.1159/000052069. 

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