α5β1 is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. It is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. It is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1).
- Boudreau NJ, Varner JA (February 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis". J. Biol. Chem. 279 (6): 4862–8. PMID 14610084. doi:10.1074/jbc.M305190200.
- Theisen, U; Straube, E; Straube, A (Dec 11, 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions.". Developmental cell 23 (6): 1153–66. PMID 23237952. doi:10.1016/j.devcel.2012.11.005.
- Integrin alpha5beta1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGA5 ITGB1 Info with links in the Cell Migration Gateway
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