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Open Access Articles- Top Results for Alpha 2-antiplasmin

Alpha 2-antiplasmin

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Identifiers
SymbolsSERPINF2 ; A2AP; AAP; ALPHA-2-PI; API; PLI
External IDsOMIM613168 MGI107173 HomoloGene719 GeneCards: SERPINF2 Gene
RNA expression pattern
File:PBB GE SERPINF2 205075 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez534518816
EnsemblENSG00000167711ENSMUSG00000038224
UniProtP08697Q61247
RefSeq (mRNA)NM_000934NM_008878
RefSeq (protein)NP_000925NP_032904
Location (UCSC)Chr 17:
1.65 – 1.66 Mb
Chr 11:
75.43 – 75.44 Mb
PubMed search[1][2]

Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.[1]

File:Fibrinolysis.png
Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

Role in disease

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. This is associated with an increase risk of bleeding in liver disease. [2]

Interactions

Alpha 2-antiplasmin has been shown to interact with:

See also

References

  1. ^ "Entrez Gene: SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2". 
  2. ^ Sattar, Husain. Fundamentals of Pathology. Pathoma LLC, 2011, p. 36.
  3. ^ a b Shieh BH, Travis J (May 1987). "The reactive site of human alpha 2-antiplasmin". The Journal of Biological Chemistry 262 (13): 6055–9. PMID 2437112. 
  4. ^ Brower MS, Harpel PC (Aug 1982). "Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase". The Journal of Biological Chemistry 257 (16): 9849–54. PMID 6980881. 
  5. ^ Wiman B, Collen D (Sep 1979). "On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin". The Journal of Biological Chemistry 254 (18): 9291–7. PMID 158022. 

Further reading

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External links

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