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Open Access Articles- Top Results for Amedalin

Amedalin

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Amedalin
File:Amedalin.png
Systematic (IUPAC) name
3-methyl-3-[3-(methylamino)propyl]-1-phenyl-1,3-dihydro-2H-indol-2-one
Clinical data
Identifiers
22136-26-1 7pxY
22232-73-1 (HCl)
None
PubChem CID 31075
ChemSpider 28832 7pxY
UNII 2OWK6X9N16 7pxY
ChEMBL CHEMBL2110769 7pxN
Chemical data
Formula C19H22N2O
294.3925 g/mol
 14pxN (what is this?)  (verify)

Amedalin (UK-3540-1) is an antidepressant which was synthesized in the early 1970s, but was never marketed.[1][2] It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.[2] [3]

References

  1. ^ David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9. 
  2. ^ a b Canas-Rodriquez A, Leeming PR (1972). "N-Phenyl-2-indolinones and N-phenylindolines - New class of antidepressant agents". Journal of Medicinal Chemistry 15 (7): 762–770. doi:10.1021/jm00277a017. 
  3. ^ Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". Journal of Pharmacology and Experimental Therapeutics 199 (3): 649–661. 


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