Open Access Articles- Top Results for Amibegron


Systematic (IUPAC) name
Ethyl ([(7S)-7-([(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)acetate
Clinical data
PubChem CID 3035442
IUPHAR ligand 568
ChemSpider 108738 7pxY
KEGG D08851 7pxY
ChEMBL CHEMBL545437 7pxY
Chemical data
Formula C22H26ClNO4
403.898 g/mol
 14pxY (what is this?)  (verify)

Amibegron (SR-58,611A) is a drug developed by Sanofi-Aventis which acts as a selective agonist for the β3 adrenergic receptor. It is the first orally active β3 agonist developed that is capable of entering the central nervous system, and has antidepressant and anxiolytic effects.[1][2]

On July 31, 2008, Sanofi-Aventis announced that it has decided to discontinue development of amibegron.[3]


  1. ^ Stemmelin J, Cohen C, Terranova JP, Lopez-Grancha M, Pichat P, Bergis O, Decobert M, Santucci V, Françon D, Alonso R, Stahl SM, Keane P, Avenet P, Scatton B, le Fur G, Griebel G. Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychopharmacology. 2008 Feb;33(3):574-87. PMID 17460614
  2. ^ Overstreet DH, Stemmelin J, Griebel G. Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression. Pharmacology, Biochemistry and Behaviour. 2008 Jun;89(4):623-6. doi:10.1016/j.pbb.2008.02.020 PMID 18358519
  3. ^ Second quarter 2008 results. July 31, 2008, retrieved March 9, 2009.

Lua error in package.lua at line 80: module 'Module:Buffer' not found.