Open Access Articles- Top Results for Amorolfine


Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
78613-35-1 7pxY
PubChem CID 54260
ChemSpider 49010 7pxY
KEGG D02923 7pxY
ChEBI CHEBI:599440 7pxY
ChEMBL CHEMBL489411 7pxY
Chemical data
Formula C21H35NO
317.509 g/mol
 14pxY (what is this?)  (verify)

Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.[1]

It is a topical solution for the treatment of toenail infections. Systemic treatments may be considered more effective.[1]

It is approved for sale over the counter in Australia and the UK (recently re-classified to over the counter status), and is approved for the treatment of toenail fungus by prescription in other countries. It is not approved for the treatment of onychomycosis in the United States or Canada, but can be ordered from there by mail from other countries.[2]


  1. ^ a b Hywel C. Williams (2003). Evidence-Based Dermatology. Blackwell. 
  2. ^ It can readily be verified that Curanail is advertised on websites such as US, shipped from abroad.