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Open Access Articles- Top Results for Amthamine

Amthamine

Amthamine
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This page is a soft redirect. Names

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IUPAC name
5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine
Other names
5-(2-aminoethyl)-4-methyl-2-thiazolamine
2-amino-5-(2-aminoethyl)-4-methylthiazole
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142437-67-0 7pxY
ChEMBL ChEMBL293762 7pxY
ChemSpider 112538 7pxY
Jmol-3D images Image
Image
PubChem Template:Chembox PubChem/format
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C6H11N3S
Molar mass 157.236 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Amthamine is a histamine agonist selective for the H2 subtype.[1] It has been used in vitro and in vivo to study gastric secretion,[2] as well as other functions of the H2 receptor.[3][4][5]

References

  1. ^ Eriks JC, van der Goot H, Sterk GJ, Timmerman H. Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles. Journal of Medicinal Chemistry. 1992 Aug 21;35(17):3239-46. PMID 1507209
  2. ^ Coruzzi G, Timmerman H, Adami M, Bertaccini G (July 1993). "The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion". Naunyn Schmiedebergs Arch Pharmacol 348 (1): 77–81. PMID 8377843. doi:10.1007/BF00168540. 
  3. ^ Ezeamuzie CI, Philips E. Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation. British Journal of Pharmacology. 2000 Oct;131(3):482-8. PMID 11015298
  4. ^ Fernandez N, Monczor F, Baldi A, Davio C, Shayo C. Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization. Molecular Pharmacology. 2008 Oct;74(4):1109-18. PMID 18617631
  5. ^ Threlfell S, Exley R, Cragg SJ, Greenfield SA. Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra. Journal of Neurochemistry. 2008 Nov;107(3):745-55. PMID 18761715


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