Adverts

Open Access Articles- Top Results for Anistreplase

Anistreplase

</th></tr></th></tr>
Anistreplase
Clinical data
Trade names Eminase
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pharmacokinetic data
Half-life 90 minutes
Identifiers
81669-57-0 7pxY
B01AD03
DrugBank DB00029 7pxY
KEGG D02947 7pxY
Chemical data
approx. 131,000 g/mol
 14pxY (what is this?)  (verify)

Anistreplase is a thrombolytic drug.[1][2][3]

Anistreplase has been developed by Beecham as Eminase. It is also known as anisoylated plasminogen streptokinase activator complex (APSAC)

Mechanism

It is a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme's active site. When the drug is administered, the acyl group gets hydrolyzed, thereby freeing the activator complex. It converts plasminogen to plasmin, which in turn degrades fibrin (blood clots) to fibrin split products.

References


Lua error in package.lua at line 80: module 'Module:Buffer' not found.