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Anterior grey column

Anterior grey column (Anterior horn of spinal cord)
Latin Cornu anterius medullae spinalis
Gray's p.753
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Anatomical terminology

The anterior grey column (also called the anterior cornu, anterior horn of spinal cord or ventral horn) is the front column of grey matter in the spinal cord. It is one of the three grey columns. The anterior grey column contains motor neurons that affect the axial muscles while the posterior grey column receives information regarding touch and sensation. The anterior grey column is the column where the cell bodies of alpha motor neurons are located.


The anterior grey column, directed forward, is broad and of a rounded or quadrangular shape. Its posterior part is termed the base, and its anterior part the head, but these are not differentiated from each other by any well-defined constriction. It is separated from the surface of the medulla spinalis by a layer of white substance which is traversed by the bundles of the anterior nerve roots. In the thoracic region, the postero-lateral part of the anterior column projects laterally as a triangular field, which is named the lateral grey column.

Clinical significance

It is these cells that are affected in the following diseases,[citation needed]amyotrophic lateral sclerosis, Charcot–Marie–Tooth disease, progressive muscular atrophy, all spinal muscular atrophies, poliomyelitis, and West Nile virus.

Pharmacological interaction

The anterior grey column is the target for some spasmolytic medications. Norepinephrine release here, (as induced by cyclobenzaprine) reduces spasms by innervation (reducing nerve activity) of alpha motor neurons via interaction with gamma fibers.[1]

See also

Additional images


This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918)

  1. ^ "Cyclobenzaprine". DrugBank.